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The physician has to weigh the benefits of the treatment against the potential teratogenic effects before using atrium health primary care albemarle family medicine drug during pregnancy. Among the drugs prescribed during pregnancy, antihistamines are one of the commonest, either as an antipruritic agent or an antiemetic agent.

Various atrium health primary care albemarle family medicine on the use of antihistamines H check this out blockers during pregnancy, including a meta-analysis of more thanwomen shows no increase in the teratogenic risk of these drugs in the humans.

Drugs such as dexchlorpheniramine and alimemazine trimeprazine were not found to have any teratogenic effect even in animal studies. None of the antihistamines has been so far declared safe during the pregnancy by FDA on the basis of controlled animal or human studies. The first generation antihistamines include drugs such as diphenhydramine, cyproheptadine, promethazine, chlorpheniramine, and hydroxyzine.

They have a very potent effect with high lipophilicity but are short acting. They are metabolized in the liver by the microsomal cytochrome P system. The common side effects of this category of antihistamines include sedation and anticholinergic effects-dryness of the mouth, blurring of vision, constipation and urinary source. FDA has categorized the first generation antihistamines according to the pregnancy complications [ Table 1 ].

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