University of louisville school of medicine
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Drugs such care tn dexchlorpheniramine and alimemazine trimeprazine were not found to have any teratogenic effect even in animal studies. None of the antihistamines has been so far declared university of louisville school of medicine during the pregnancy university of louisville school of medicine FDA on the basis of controlled animal or human studies.
The first generation antihistamines include drugs such as diphenhydramine, cyproheptadine, promethazine, chlorpheniramine, and hydroxyzine. They have a very potent effect with high lipophilicity but are short acting.
They mediicne metabolized in the liver by the microsomal cytochrome P system. The common side effects of this category of antihistamines include sedation and anticholinergic effects-dryness of the mouth, blurring of vision, constipation and urinary retention.
FDA has categorized the first generation antihistamines according to the pregnancy complications [ Table 1 ]. Michigan Medicaid Birth Defects study has linked hydroxyzine to cleft palate in new borns.
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